Marvel Biosciences’ Lead Drug Candidate MB-204 Successfully Targets Brain Receptor Important for Alzheimer’s Disease and Depression
Calgary, Alberta–(November 7, 2022) – Marvel Biosciences Corp. (TSXV: MRVL) and its wholly owned subsidiary, Marvel Biotechnology Inc. (collectively the “Company“ or “Marvel“), announced today that in a pre-clinical mouse study conducted by the Company, its lead drug candidate MB-204 successfully entered the brain and occupied its target, the adenosine A2a receptor. The adenosine A2a receptor has been validated by numerous scientific studies that it plays a significant role in various pathologies such as Alzheimer’s Disease and depression.
“We previously reported that MB-204 independently improved depression-like symptoms in mice,” said Dr Mark Williams, Chief Science Officer of Marvel Biosciences. “This study further validates this observation as we have confirmed in our study that MB-204 enters the brain and engages its target, the adenosine A2a receptor, and reduces depression. In fact, there was more occupation after four hours than one hour, which matched what we saw in the blood of animals after dosing. We believe this is vital as:
- it suggests MB-204 should be able to treat other diseases associated with the adenosine A2a receptor such as Alzheimer’s disease, Fragile X syndrome and ADHD and;
- it will ultimately help to convince both physicians and potential future large pharmaceutical partners about the mechanism of action of our drug, making it a more attractive partnership candidate.”
MB-204 is a fluorinated derivative of the U.S. FDA approved adenosine A2a receptor antagonist, Istradefylline. Both Istradefylline and MB-204 are highly active derivatives of caffeine, the most widely consumed psychoactive drug in the world. Caffeine consumption has been associated with a reduced risk for developing Parkinson’s disease, Alzheimer’s disease and improving concentration.
About Marvel Biosciences Corp.
Marvel Biosciences Corp., and its wholly owned subsidiary, Marvel Biotechnology Inc., is a Calgary-based pre-clinical stage pharmaceutical development biotechnology company that utilizes a “drug redevelopment” approach to drug development. Historically, when a new class of drug is developed, it is optimized for a particular target, but typically only approved for a specific disease. Often, a new disease is identified which involves the same target, however, pending the remaining patent life, the originally approved drug may not have sufficient time left for it to be commercially viable to be developed for the new disease indication. Marvel develops new synthetic chemical derivatives of the original approved drug for the new disease indication. Patent protection is sought, as the new potential asset is developed by the Company. The Company believes the business model results in significantly less risk, cost and time to develop its assets compared to traditional biotechnology companies.
Marvel Biotechnology Inc. has currently developed several new chemical entities, using synthetic chemical derivatives of known, off-patent drugs, that inhibit the A2a adenosine receptor with application to neurological diseases (depression & anxiety, Alzheimer’s, ADHD), and the non-neurological conditions of cancer and non-alcoholic steatohepatitis. Marvel is also exploring additional undisclosed targets to expand its asset pipeline.
Investor Relations Marvel Biosciences Corp.
Virtus Advisory Group Roderick (Rod) Matheson, Chief Executive Officer or
Tel: 416-644-5081 Dr. Mark Williams, President, and Chief Science Officer
Tel: 403 770 2469
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